浙大附一传染病国家重点实验室论文因数据完整性存疑遭撤回

A novel Fas-binding outer membrane protein and lipopolysaccharide of Leptospira interrogans induce macrophage apoptosis through the Fas/FasL-caspase-8/-3 pathway

一种新的Fas结合外膜蛋白和质询钩端螺旋体脂多糖通过Fas/FasL-半胱氨酸8/-3途径诱导巨噬细胞凋亡

作者：隐去，不公布

单位：

1Division of Basic Medical Microbiology, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310003, People's Republic of China.

2Department of Medical Microbiology and Parasitology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058, People's Republic of China.

3Faculty of Basic Medicine, Hangzhou Medical College, Hangzhou, Zhejiang, 310053, People's Republic of China.

4Institute of Communicable Disease Prevention and Control, Guizhou Provincial Centre for Disease Control and Prevention, Guiyang, Guizhou, 550004, People's Republic of China.

5Department of Biomedical Sciences, University of the Pacific, Arthur Dugoni School of Dentistry, 155 Fifth Street, San Francisco, CA, 94103, USA.

6Division of Basic Medical Microbiology, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310003, People's Republic of China.

7Department of Medical Microbiology and Parasitology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058, People's Republic of China.

8Faculty of Basic Medicine, Hangzhou Medical College, Hangzhou, Zhejiang, 310053, People's Republic of China.

9Division of Basic Medical Microbiology, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310003, People's Republic of China.

10Department of Medical Microbiology and Parasitology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058, People's Republic of China.

11Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou, Zhejiang, 310003, People's Republic of China.

1浙江大学医学院附属第一医院传染病诊治国家重点实验室医学微生物学基础科，浙江杭州，310003。

2浙江大学医学院医学微生物学与寄生虫学系，浙江杭州，310058。

3基础医学专业，杭州医学院，浙江杭州，310053。

4贵州省疾病预防控制中心传染病预防控制所，贵州贵阳，550004。

5太平洋大学生物医学系，Arthur Dugoni牙科学院，美国加利福尼亚州旧金山第五街155号，94103。

6浙江大学医学院附属第一医院传染病诊治国家重点实验室医学微生物学基础科，浙江杭州，310003。

7浙江大学医学院医学微生物学与寄生虫学系，浙江杭州，310058。

8杭州医学院基础医学院，浙江杭州，310053。

9浙江大学医学院附属第一医院传染病诊治国家重点实验室基础医学微生物学处，浙江杭州，310003。

10浙江大学医学院医学微生物学与寄生虫学系，浙江杭州，310058。

11浙江大学传染病诊疗协同创新中心，浙江杭州，310003。

撤稿杂志：Emerg Microbes Infect

撤稿原因：数据完整性存疑及图片重复

撤稿声明：

We, the Editors and Publishers of Emerging Microbes and Infections, have retracted the following article:

A novel Fas-binding outer membrane protein and lipopolysaccharide of Leptospira interrogans induce macrophage apoptosis through the Fas/FasL-caspase-8/-3 pathway, Emerging Microbes & Infections, 7:1, 1-17, DOI: https://doi.org/10.1038/s41426-018-0135-9.

Since publication, significant concerns have been raised about the integrity of the data in the article. An initial investigation conducted resulted in the correction of Figure 2a. However, further investigations have raised wider concerns regarding the integrity of the flow cytometry and Western blot data in the article. When approached for an explanation, the authors provided responses to our queries, but they have not sufficiently addressed our concerns. As we cannot confirm the validity of the data reported, we are therefore retracting the article.

We have been informed in our decision-making by our editorial policies and the COPE guidelines. The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as “Retracted”.

我们，《新兴微生物与感染》的编辑和出版商，撤回了以下文章：

一种新型Fas结合外膜蛋白和质询钩端螺旋体脂多糖通过Fas/FasL-半胱氨酸-8/-3途径诱导巨噬细胞凋亡，新兴微生物与感染，7:1，1-17，
DOI:https://doi.org/10.1038/s41426-018-0135-9.

自发表以来，人们对文章中数据的完整性提出了重大担忧。进行的初步调查对图2a进行了更正。然而，进一步的研究对文章中流式细胞术和蛋白质印迹数据的完整性提出了更广泛的担忧。当被要求解释时，作者对我们的询问做出了回应，但他们没有充分解决我们的担忧。由于我们无法确认报告数据的有效性，因此我们撤回了这篇文章。

我们的编辑政策和《联合国气候变化框架公约》指导方针为我们的决策提供了信息。撤回的文章将保留在网上，以保持学术记录，但它将在每一页上加上“撤回”的数字水印。

浙大附一传染病国家重点实验室论文因数据完整性存疑遭撤回